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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Colchicine
supplement:
Glycine
Research Papers that Mention the Interaction
“However, the Gly to Val mutation significantly increased the stimulation of the MDR1-ATPase by colchicine and etoposide, while slightly decreasing its stimulation by vincristine.”
Altered Drug-stimulated ATPase Activity in Mutants of the Human Multidrug Resistance Protein (*)“In a final concentration of … x 10-3 M colchicine , methyl- bis -( beta -chloro-ethyl)-amine·HCl (MBA), and urethane inhibited the synthesis … creatine, the methylation of nicotanamide, and conjugation of p-aminobenzoic acid with glycine , of morphine with glucuronic acid, and of … with sulfuric acid to varying degrees.”
“… free glycine …, colchicine , Nocodazole, and 2,4-dinitrophenol (2,4-DNP).6.Comparative studies of other amino acids [3H-leucine,3H-serine,3H-glutamic acid,3H-… demonstrates, for the first time, that a free amino acid, glycine, is transported in the retrograde direction within a select group of axons.”
Selective retrograde axonal transport of free glycine in identified neurons ofAplysia“ Colchicine at (0.1 mM) increased the "apparent Km" of glucose (140% … than 0.001) galactose (135% P less than 0.001) glycine (43% P less than 0.001) and valine (47% P less than 0.…) but had no significant effect on the p.d.max of these substrates.”
“ Colchicine elicited concentration-dependent inhibitory effects on α 3GlyRs at micromolar range and decreased the apparent affinity for glycine.”
Inhibition of the Glycine Receptor alpha 3 Function by Colchicine
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