Possible Interaction: Colchicine and Glycerol

“Animals treated with colchicine showed marked signs of inner ear malfunction after additional treatment with glycerol , which might indicate that the secretory activity in the sac is closely related to the regulation of inner ear fluid homeostasis and functional disturbance.”

“ Colchicine caused a disturbed secretory activity of the sac induced by glycerol.”

“Inhibition of colchicine binding was significant with glycerol , polyethylene glycol 1000 (PEG-2) and the ions Al(III), Co(II), Ni(II), while compounds structurally related to glycerol (glucose and sucrose) did not inhibit it.”

“These findings indicate that colchicine affects the inner ear fluid regulating mechanisms which may lead to severe functional derangement after additional glycerol treatment.”

“Treatment with glycerol following pretreatment with colchicine , however, induced marked inner ear dysfunction with impaired sense of balance and audition.”

“Abstract When mammalian cells are cooled at sub-optimal rates to −196 °C in the presence of the cryoprotectants DMSO and glycerol , pretreatment of the cells with colchicine will significantly enhance the survival of these cells as assayed after thawing.”