supp.ai
Discover Supplement-Drug Interactions
Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 3 years ago
drug:
Colchicine
supplement:
Glutathione
Research Papers that Mention the Interaction
“Transduced cells growing in 1280 ng/ml colchicine had about 3-fold higher total glutathione S-transferase activity than nontransduced cells and 2.5-fold higher activity than transduced cells growing in 60 ng/ml colchicine.”
Transduction of NIH 3T3 cells with a retrovirus carrying both human MDR1 and glutathione S-transferase pi produces broad-range multidrug resistance.“P-gly and GSH levels increased gradually during the exposure to colchicine , reaching 2.35 and 3.21 fold each.”
“ colchicine injection significantly increased lipid peroxidation, depleted reduced glutathione levels and decreased acetyl cholinesterase (AChE) activity in rat brains.”
Protective role of curcumin on colchicine-induced cognitive dysfunction and oxidative stress in rats“With the administration of colchicine after exercise, [ GSH ] was higher than in the untreated exercise group 48 h after exercise, indicating an inhibition of the ability of leucocytes to produce oxidative stress.”
Help us improve supp.ai, we'd love to hear your feedback: Submit Feedback