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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Colchicine
supplement:
Gamma-Aminobutyric Acid
Research Papers that Mention the Interaction
“Co-application of GABA (10 microM) with colchicine (100 microM) resulted in a 59.9% inhibition of GABA-gated chloride currents.”
Colchicine inhibits GABAA receptors independently of microtubule depolymerization“By use of a rapid drug perfusion system, colchicine (10-1000 microM) significantly inhibited GABA currents recorded from L(tk-) cells stably transfected with human alpha 1 beta 2 gamma 2L GABAA receptor subunits.”
“Here we report another central nervous system action of colchicine , competitive antagonism of gamma-aminobutyric acid (GABA)A receptor function.”
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