Possible Interaction: Colchicine and Calcium Supplement

“ Colchicine also inhibits both the extent and the rate of exocytosis triggered by receptor activation or by Ca2+ ionophore, demonstrating that microtubule‐dependent movement of secretory vesicles plays an important role in the exocytic response.”

“It is … of Ca++ in histamine secretion induced by antigen, anti-IgE and f-met peptide (but … dissociation constant of about 1.2 x 10(-5) M. The addition of colchicine with zinc fails to increase the inhibition caused by … two compounds work via a common mechanism of action.”

“Inhibition of the microtubule network by colchicine reduced aTEPA by ca.”

“Pretreatment with colchicine was more effective in blocking the influx of calcium into the cells than pretreatment with cytochalasin B. These drugs also prevented the characteristic increase in O(2) uptake, which is usually observed after glucagon administration.”

“The cytoskeletal disrupters colchicine and cytochalasin B were found to speed Ca2+ channel decline in ATP, whereas the cytoskeletal stabilizers taxol and phalloidin were found to prolong Ca2+ channel activity without ATP.”

“ Colchicine and cytochalasin-B at different concentrations inhibited significantly (P less than 0.001) calcium accumulation in rat intestinal cells, whereas procaine at different concentrations increased significantly (P less than 0.001) calcium accumulation in the rat small intestine.”

“Unidirectional influx of calcium across the rat small intestine was significantly inhibited (P less than 0.01) in the presence of colchicine and cytochalasin-B in the preincubation medium.”

“The mechanism of internalization may also require the action of microfilaments as well as intact microtubules, since both cytochalasin B and colchicine inhibited the uptake of CA 125I.”

“ CA2+ currents, analyzed by voltage clamp techniques, were rapidly depressed by intracellular injection of colchicine and more slowly depressed by external application.”

“The axonal transport of calcium was blocked by the neurotubule binding alkaloid, colchicine , and by the inhibition of perikaryal protein synthesis with cylcoheximide.”

“In our hands, the administration of colchicine (2.5 mg/kg iv) produced a decrease in ionized calcium ( Ca++ ) from 4.51 ± 0.08 to 3.61 ± 0.24 mg/100 ml; concomitantly, immunoreactive plasma PTH increased from 80 ± 10 to 287 ± 23 pg/ml.”