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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Colchicine
supplement:
Ascorbate
Research Papers that Mention the Interaction
“Furthermore, ascorbate acutely stabilized microtubules during depolymerization induced by colchicine and nocodazole.”
Intracellular ascorbate tightens the endothelial permeability barrier through Epac1 and the tubulin cytoskeleton.“The increase in barrier function due to ascorbate was dependent on its intracellular concentration, significant by 15 min of incubation, prevented by the cytoskeletal inhibitor colchicine , associated with F-actin stress fiber formation, and not due to collagen deposition.”
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