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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Colchicine
supplement:
Adrenocorticotropic Hormone
Research Papers that Mention the Interaction
“ Colchicine and ACTH had additive effects on corticosterone production, whereas colchicine and PMA did not, implying that part of the PKC signaling mechanism may be involved in colchicine‐induced steroidogenesis.”
Mechanism of colchicine‐induced steroidogenesis in rat adrenocortical cells“Administration of colchicine resulted in a long-lasting and dose-dependent stimulation of ACTHi secretion.”
“Intracerebroventricular administration of colchicine resulted in a marked decrease in the number of ACTH and beta-endorphin nerve fibers and a significant reduction in ACTH and beta-endorphin content in the dorsolateral hypothalamus.”
“A significant augmentation of corticosteroids in the serum and adrenal gland resulted when colchicine was administered 60 minutes prior to the injection of adrenocorticotropic hormone.”
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