“ Quinine as well as the other inhibitors inhibited both EM and CD O-dealkylation competitively and with small differences in Ki versus EM and CD, respectively.”
“ Quinine was the most potent inhibitor of both these O-dealkylations (Ki = 0.2 microM for both EM and CD , respectively).”
“ Quinine , quinidine, propafenone and sparteine all inhibited EM O-deethylation as well as CD O-demethylation.”