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Last Updated: 3 months ago

Possible Interaction: Codeine and Quinidine

drug:

Codeine

supplement:

Quinidine

Research Papers that Mention the Interaction

Conclusion: Quinidine penetrates the blood brain barrier poorly, but quinidine pre-treatment leads to pronounced lowering of the cerebrospinal fluid concentration of morphine after codeine intake.
Eight patients were given an oral dose of 125 mg codeine and 9 patients (including the poor metaboliser) were given 200 mg quinidine 2 h before the same dose of codeine.
European Journal of Clinical Pharmacology  •  2004  |  View Paper
At treatment week 8, placebo, quinidine , and fluoxetine reduced mean daily codeine intake by 57%, 56%, and 51% of baseline intake respectively; there was no difference among treatment groups.
Journal of clinical psychopharmacology  •  2002  |  View Paper
Short-term quinidine pretreatment inhibited codeine O-demethylation more than did single-dose quinidine pretreatment (p < 0.01), and it decreased positive codeine effects in the FD120 group (N = 7), but unexpectedly not in the FD180 group (N = 5).
Single-… quinidine pretreatment significantly decreased the recovery of O-demethylated metabolites in plasma (p < 0.01) and resulted in a decrease in the positive (e.g., "high," p < 0.05) and negative (e.g., nausea, p < 0.05) subjective effects of codeine in both the FD120 and FD180 groups.
Journal of clinical psychopharmacology  •  2000  |  View Paper
Codeine O-demethylation was significantly reduced after quinidine in both ethnic groups; however, the absolute decrease was greater in Caucasians (115.8 +/- 25.9 ml/min versus 46.8 +/-
Codeine O-demethylation was significantly reduced after quinidine in both ethnic groups; however, the absolute decrease was greater in Caucasians (115.8 +/- 25.9 ml/min versus 46.8 +/- 10.6 ml/min, respectively, p <.03).
In addition, quinidine induced inhibition of codeine O-demethylation is ethnically dependent with the reduction being greater in Caucasians.
The Journal of pharmacology and experimental therapeutics  •  1999  |  View Paper
Quinidine and lignocaine, although they are substrates of CYP3A, showed preferential inhibition over the O-demethylation of codeine , suggesting a low affinity to the CYP3A.
European Journal of Clinical Pharmacology  •  1997  |  View Paper
Lack of morphine formation from codeine as a result of CYP2D6 inhibition by quinidine results in an almost complete loss of the analgesic effects of codeine.
Clinical Pharmacokinetics  •  2002  |  View Paper
Quinidine has been observed to inhibit the metabolism of digoxin, tricyclic antidepressants and codeine.
Drug safety  •  2000  |  View Paper
Quinine, quinidine , propafenone and sparteine all inhibited EM O-deethylation as well as CD O-demethylation.
Biochemical pharmacology  •  1995  |  View Paper