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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
Research Papers that Mention the Interaction
“Eight patients were given an oral dose of 125 mg codeine and 9 patients (including the poor metaboliser) were given 200 mg quinidine 2 h before the same dose of codeine.”
“Lack of morphine formation from codeine as a result of CYP2D6 inhibition by quinidine results in an almost complete loss of the analgesic effects of codeine.”
“ Quinidine has been observed to inhibit the metabolism of digoxin, tricyclic antidepressants and codeine.”
“ Quinidine and lignocaine, although they are substrates of CYP3A, showed preferential inhibition over the O-demethylation of codeine , suggesting a low affinity to the CYP3A.”
Different effects of inhibitors on the O - and N -demethylation of codeine in human liver microsomes“Quinine, quinidine , propafenone and sparteine all inhibited EM O-deethylation as well as CD O-demethylation.”
Ethylmorphine O-deethylation in isolated rat hepatocytes. Involvement of codeine O-demethylation enzyme systems.
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