Possible Interaction: Cocaine and Yohimbine

“These effects of cocaine were reversed by further addition of yohimbine.”

“Oxymetazoline and α-methyl-noradrenaline did not cause desensitization of the presynaptic adrenoceptors when present … IC80 for 33 min.3.At a perfusion rate of 7 ml/min, yohimbine 1 μM enhanced the stimulation-evoked 3H-noradrenaline overflow by … the absence, and by 58% in the presence of cocaine.”

“Addition of yohimbine prevented the depressant effect of desipramine on the EJCs completely and reduced that of cocaine , but increased their effects on the Δ[NA]CF response.”

“… cocaine (… yohimbine (1 μM), amitriptyline (0.5–1 μM), desipramine (1–3 μM) and iprindole (5–10 μM), desipramine (1–3 μM) and iprindole (5–10 … of the concentration-response curve for the inhibitory effect of carbachol (CCh) on responses to electrical stimulation of the preparation at 3 Hz.”

“Co‐administration of equimolar doses (250 pmoles) of prazosin, naftopidil, yohimbine or rauwolscine significantly reversed those effects elicited by cocaine on cEEG, hEEG and ICP.”

“In the presence of cocaine, yohimbine (10(-6)M) enhanced stimulation-evoked [3H]-noradrenaline release.”

“The bradycardic response to cocaine was attenuated by yohimbine (0.1 mg/kg i.v.),”

“Phentolamine, prazosin and yohimbine also reduced the tachycardiac effect of cocaine , although these effects were dose-dependent only for yohimbine, which also significantly elevated baseline heart rate.”

“In conscious rats, pretreatment with dl-, d- or l-propranolol or the alpha 2-selective adrenoceptor antagonist yohimbine enhanced the convulsive and lethal effects of cocaine.”

“2 Yohimbine and idazoxan (0.01 to 1 μm) increased fractional evoked overflow of tritium by up to 2 fold; in the presence of these drugs, cocaine (10 μm) produced an increase in both tissues (up to 3.5 fold over control).”