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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
Research Papers that Mention the Interaction
“… xylazine at inhibiting stimulation-… presence of cocaine was significantly reduced in knockout (pD(2) of 8.27+/-0.07, -log M, n=4) as compared with wild-type …<0.05), whereas potency of MDMA was unchanged (5.39+/-0.06, n=4 versus 5.38+/-0.06, n=6).”
Prejunctional actions of methylenedioxymethamphetamine in vas deferens from wild-type and alpha(2A/D)-adrenoceptor knockout mice.“ Cocaine acted synergistically with XLZ , decreasing the ED50 from 0.42 to 0.13 mg/kg.”
“While XLZ alone (0.5 mg/kg, sc) inhibited the contortions by 43%, cocaine (5 mg/kg, sc) produced 39% inhibition and combination of the two drugs reduced the contortions by 77%.”
“ Cocaine differentially potentiated the effects of the sympathomimetic amines used such that the relative order of agonist potency was … than (+)-noradrenaline greater than (-)-metaraminol greater than or equal to (-)-noradrenaline greater than or equal to dopamine, to xylazine greater than (-)-adrenaline greater than (-)-noradrenaline … than or equal to (+)-noradrenaline.”
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