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Last Updated: 3 years ago

Possible Interaction: Cocaine and Verapamil

supplement:

Cocaine

Research Papers that Mention the Interaction

Double reciprocal plot of noradrenaline output against the Ca2+ concentration used for stimulation (….9–7.2 mM; α-adrenoceptors and neuronal uptake blocked by phentolamine and cocaine , respectively) yielded a straight line (Km=1.… mM Ca2+), and the inhibition by verapamil proved to be competitive (…=8.8 μM verapamil).
Naunyn-Schmiedeberg's Archives of Pharmacology  •  2004  |  View Paper
However, haloperidol, indomethacin, verapamil and excess [Mg++]0 (4.8 x 10(-3) M) as well as removal of [Ca++]0 completely prevented vasospasms induced by COC.
The Journal of pharmacology and experimental therapeutics  •  1994  |  View Paper
Verapamil , a calcium channel antagonist (250 μg/kg), attenuated the hemodynamic effects of cocaine and prevented the development of ventricular arrhythmias.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology  •  1988  |  View Paper
The fractional 3H-release produced by verapamil was reduced markedly in tissues which had been preloaded with [3H]NE in the presence of cocaine (10 microM) or after pretreatment of animals with reserpine (5 mg/kg i.p.,
The Journal of pharmacology and experimental therapeutics  •  1985  |  View Paper