Possible Interaction: Cocaine and Vasoconstrictor Agents

“ Cutaneous vasoconstriction is also likely to occur with amphetamine-related drugs, and with cocaine.”

“Several drug interactions must also be considered before administration of a local anesthetic with a vasoconstrictor , and special care must be taken when injecting such preparations in patients on nonspecific beta-adrenergic blockers, tricyclic antidepressants, catechol-O-methyltransferase inhibitors, cocaine , and certain general anesthetics.”

“Conclusion: Liver damage may result from the potent vasoconstrictor property of cocaine , leading to vasospasm and ischemia.”

“ Cocaine (10 microm) potentiated the coronary vasoconstriction and positive inotropy by noradrenaline indicating inhibition of neuronal uptake.”

“ Cocaine has been reported to induce coronary vasoconstriction , cardiac arrhythmias and conduction delays.”

“This vasoconstrictor effect was most pronounced at 15 min after injection of cocaine and persisted up to 60 min.”

“It has been suggested that ischemia secondary to coronary vasoconstriction is responsible for adverse cardiovascular effects of cocaine.”

“ConclusionsIn conscious dogs, cocaine induces coronary vasoconstriction , which competes with coronary vasodilator responses to increases in myocardial oxygen consumption.”

“Blockade of neuronal norepinephrine uptake with cocaine produced a greater potentiation of vasoconstrictor responses to both nerve stimulation and exogenous norepinephrine in the older rats.”

“The vasoconstrictor actions of prostaglandins E2 and F2alpha were potentiated by cocaine and inhibited by phentolamine.”