Possible Interaction: Cocaine and Tyramine

“In the cat, dog, rabbit and goat, tyramine produced a fall in pulmonary resistance, which was reduced by the administration of either reserpine or cocaine.”

“The potency of p‐tyramine and other non‐catechols (d‐amphetamine, β‐phenethylamine, MPP+) in inhibiting cocaine analog binding to DAT in digitonin‐treated cells was markedly weakened to a level similar to that observed in cell‐free membranes.”

“The pupillary reaction to both cocaine and tyramine were reduced bilaterally.”

“The main effect of injections of increasing amounts of cocaine was a graded parallel shift of the dose-response curve of tyramine to the right; the mode of action was that typical for a "surmountable" antagonist.”

“Pretreatment with cocaine (1mg/kg) did not significantly affect the tachycardia to cathinone or MDMA, but reduced the response to tyramine.”

“Similarly, pretreatment with cocaine , the classical inhibitor of uptake 1, significantly decreased the pressor effect of tyramine ; however, the response to tyramine was then restored when L-NNA was administered, thus reversing the effect of cocaine.”

“Prazosin (0.3 microM) and cocaine (10 microM) attenuated the responses induced by noradrenaline (P<0.001, n=6-7) and tyramine (P<0.001, n=5-6), respectively, in all genotypes.”

“Prazosin (0.3 muM) attenuated the responses induced by noradrenaline and EFS in all mice (P</=0.019, n=5-7), while cocaine (10 muM) attenuated the responses evoked by tyramine (P<0.001, n=6).”

“Inhibition of neuronal uptake by cocaine (8 μM) resulted in a marked reduction of the release of noradrenaline by tyramine , but did not affect the metabolic pattern of the released noradrenaline.”

“ Cocaine reduced the effects of tyramine , 3-methylindole, 5-hydroxyindole, and harmine.”