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Possible Interaction: Cocaine and Tyramine



Research Papers that Mention the Interaction

In the cat, dog, rabbit and goat, tyramine produced a fall in pulmonary resistance, which was reduced by the administration of either reserpine or cocaine.
British journal of pharmacology  •  1970  |  View Paper
The potency of p‐tyramine and other non‐catechols (d‐amphetamine, β‐phenethylamine, MPP+) in inhibiting cocaine analog binding to DAT in digitonin‐treated cells was markedly weakened to a level similar to that observed in cell‐free membranes.
Journal of neurochemistry  •  2009  |  View Paper
The pupillary reaction to both cocaine and tyramine were reduced bilaterally.
Rinsho shinkeigaku = Clinical neurology  •  1999  |  View Paper
The main effect of injections of increasing amounts of cocaine was a graded parallel shift of the dose-response curve of tyramine to the right; the mode of action was that typical for a "surmountable" antagonist.
The Journal of pharmacology and experimental therapeutics  •  1961  |  View Paper
Pretreatment with cocaine (1mg/kg) did not significantly affect the tachycardia to cathinone or MDMA, but reduced the response to tyramine.
European journal of pharmacology  •  2015  |  View Paper
Similarly, pretreatment with cocaine , the classical inhibitor of uptake 1, significantly decreased the pressor effect of tyramine ; however, the response to tyramine was then restored when L-NNA was administered, thus reversing the effect of cocaine.
European journal of pharmacology  •  2011  |  View Paper
Prazosin (0.3 microM) and cocaine (10 microM) attenuated the responses induced by noradrenaline (P<0.001, n=6-7) and tyramine (P<0.001, n=5-6), respectively, in all genotypes.
European journal of pharmacology  •  2008  |  View Paper
Prazosin (0.3 muM) attenuated the responses induced by noradrenaline and EFS in all mice (P</=0.019, n=5-7), while cocaine (10 muM) attenuated the responses evoked by tyramine (P<0.001, n=6).
The Journal of endocrinology  •  2007  |  View Paper
Inhibition of neuronal uptake by cocaine (8 μM) resulted in a marked reduction of the release of noradrenaline by tyramine , but did not affect the metabolic pattern of the released noradrenaline.
Naunyn-Schmiedeberg's Archives of Pharmacology  •  2004  |  View Paper
Cocaine reduced the effects of tyramine , 3-methylindole, 5-hydroxyindole, and harmine.
Naunyn-Schmiedeberg's Archives of Pharmacology  •  2004  |  View Paper
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