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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
Research Papers that Mention the Interaction
“These results suggest that tiagabine treatment attenuates some of the subjective effects of cocaine without affecting its cardiovascular effects.”
Tiagabine affects the subjective responses to cocaine in humans“In the present study, tiagabine (Gabatril), a GABA reuptake inhibitor, was investigated for its ability to modify the discriminative-stimulus, reinforcing, subject-rated, performance and cardiovascular effects of oral cocaine in non-treatment seeking cocaine users.”
“Gabapentin (1-30 mg/kg), tiagabine (2.5-10 mg/kg) or vigabatrin (75-250 mg/kg) attenuated the cocaine (10 mg/kg)-induced hyperactivation and in the highest doses they also decreased basal locomotor activation.”
Various GABA-mimetic drugs differently affect cocaine-evoked hyperlocomotion and sensitization.“Several medications have been reported to reduce cocaine use in double-blind, placebo-controlled clinical trials, namely baclofen, modafinil, tiagabine , and topiramate.”
Pharmacotherapy and other treatments for cocaine abuse and dependence
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