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Last Updated: 2 years ago

Possible Interaction: Cocaine and Tiagabine



Research Papers that Mention the Interaction

These results suggest that tiagabine treatment attenuates some of the subjective effects of cocaine without affecting its cardiovascular effects.
Pharmacology Biochemistry and Behavior  •  2005  |  View Paper
In the present study, tiagabine (Gabatril), a GABA reuptake inhibitor, was investigated for its ability to modify the discriminative-stimulus, reinforcing, subject-rated, performance and cardiovascular effects of oral cocaine in non-treatment seeking cocaine users.
Drug and alcohol dependence  •  2004  |  View Paper
Gabapentin (1-30 mg/kg), tiagabine (2.5-10 mg/kg) or vigabatrin (75-250 mg/kg) attenuated the cocaine (10 mg/kg)-induced hyperactivation and in the highest doses they also decreased basal locomotor activation.
European journal of pharmacology  •  2006  |  View Paper
Several medications have been reported to reduce cocaine use in double-blind, placebo-controlled clinical trials, namely baclofen, modafinil, tiagabine , and topiramate.
Current opinion in psychiatry  •  2005  |  View Paper