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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Cocaine
Research Papers that Mention the Interaction
“Significantly more blunting of the response of TSH to TRH was shown in cocaine and phencyclidine abusers compared with that seen in controls.”
Blunting of TSH response to TRH in chronic cocaine and phencyclidine abusers.“Moreover, cross-sensitization between cocaine and TRH has also been demonstrated.”
“When co-administered with cocaine for 5 days during the development of sensitization, TRH (10 mg/kg) enhanced the effect of the challenge dose of cocaine (10 mg/kg) following a 5-day withdrawal.”
Effect of thyrotropin-releasing hormone on the locomotor and sensitizing effects of cocaine in rats“A radioimmunoassay (RIA) study showed that a single dose of cocaine increased the TRH level in the striatum by 68%, but had no significant effect on the peptide content in the nucleus accumbens, hippocampus, amygdala, septum, hypothalamus, frontal and prefrontal cortex at 45 min after the drug injection.”
“Repeated administration of cocaine increased the TRH level in the striatum by 89% at 45 min, and in the hippocampus by 26% at 72 h after the last dose.”
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