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Last Updated: 3 years ago

Possible Interaction: Cocaine and Thioridazine

supplement:

Cocaine

Research Papers that Mention the Interaction

In contrast, in the presence of a therapeutic concentration of thioridazine, cocaine concentrations decreased by only 71% during this period of time, and, with a toxic concentration of thioridazine, cocaine concentrations decreased by only 55%.
These findings suggest that thioridazine may prolong the serum half-life of cocaine by inhibiting the pseudocholinesterase-mediated catabolism of cocaine to ecgonine methyl ester.
Therapeutic drug monitoring  •  2005  |  View Paper