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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Cocaine
drug:
Tetrodotoxin
Research Papers that Mention the Interaction
“By contrast, TTX greatly attenuated the Fos response evoked by cocaine or GBR 12909.”
Dopamine D1 Receptors Synergize with D2, But Not D3 or D4, Receptors in the Striatum without the Involvement of Action Potentials“In contrast, coadministration of either tetrodotoxin (Na+ channel blocker), charybdotoxin (K+ channel blocker), or quinacrine (phospholipase A2 inhibitor), or pretreatment with indomethacin (cyclooxygenase inhibitor) attenuated vasoconstriction induced by cocaine.”
“Vasoconstriction induced by topically applied cocaine was blocked by tetrodotoxin (10-7 M, Na+ channel blocker), whereas phentolamine (10-5 M, nor-adrenergic receptor blocker) had no effect on the arteriolar response to cocaine, which suggested that cocaine effected constriction by an anesthetic and not a sympathomimetic mechanism.”
“ Tetrodotoxin (TTX), which prevents action potentials by blocking voltage‐dependent Na+ channels, did not prevent d‐amphetamine induced increases in extracellular DA, but blocked completely the effects of cocaine , nomifensine, bupropion, and methylphenidate.”
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