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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
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Cocaine
Research Papers that Mention the Interaction
“Additionally, stereotypy resulted from the combination of THC with methamphetamine, cocaine , or apomorphine.”
“Cortical and hippocampal alterations produced by THC were antagonized by methamphetamine, cocaine , and caffeine and only briefly by apomorphine.”
EEG and behavioral effects of Δ9-Tetrahydrocannabinol in combination with stimulant drugs in rabbits“ THC users had a tendency to use cocaine and amphetamines more frequently than THC abstainers.”
“Acute treatment with CP 55,940 decreased cocaine choice, whereas THC and rimonabant enhanced the reinforcing effects of cocaine.”
“SIGNIFICANCE STATEMENT Co-abuse of tetrahydrocannabinol and cocaine is a significant public health problem.”
Cannabinoid Modulation of Food-Cocaine Choice in Male Rhesus Monkeys“Use of this place conditioning method has allowed us to determine that, when administered during periods of sensorimotor vocal learning, delta-9-THC , but not nicotine persistently increases sensitivity to cocaine through adulthood.”
“However, the reinforcing effects of cocaine were potentiated in rats treated with THC during adolescence, but this effect was only observed with small doses of cocaine.”
“Together, these results demonstrate that exposure to THC during adolescence may enhance sensitivity to cocaine and/or enhance the reinforcing effects of cocaine even into adulthood under certain conditions.”
“However, following a cocaine challenge, adolescents exposed to THC showed increased locomotor responses to cocaine compared to chronic vehicle-injected controls.”
“These results show that the effects of cocaine are enhanced after THC in adolescents, but not adults, and that this might account for the greater transition to cocaine after early, as opposed to later, marijuana use.”
“However, both cocaine and amphetamine and D2-, but not the D1-, receptor agonists, augmented THC discrimination.”
“Experiment 2 examined how this regimen of THC pre-exposure alters the locomotor effects of cocaine and heroin.”
“When given cocaine, THC-exposed rats exhibited normal increases in locomotion, but they avoided the center of the open field, suggesting that this THC pre-exposure regimen enhances the anxiogenic effects of cocaine.”
“These findings link the sites of rewarding action of Δ9THC to brain regions where such drugs as amphetamines, cocaine , heroin, and nicotine are also thought to have their sites of rewarding action.”
“Pretreatment with THC instead of CBD could similarly increase brain levels of cocaine , PCP, and CBD, although with a lower potency than CBD.”
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