“ Benzoylecgonine formation was significantly reduced, and its t1/2 was significantly prolonged after administration of COC+ALC in the ALC-naive and the ALC-pretreated rats.”
“In the ALC-naive rats, COC area under the plasma concentration-time curve (AUC) and maximum plasma concentration (Cpmax) were significantly higher after administration of COC+ALC compared with after administration of COC+NS.”