Possible Interaction: Cocaine and Sulpiride

“Administration of the selective D2 receptor antagonist (−)-sulpiride (25 mg/kg) before the challenge dose of cocaine completely antagonized the increase in defensive behaviour, while the selective D1 receptor antagonist SCH 23390 (0.25–0.50 mg/kg) did not significantly affect defensive behavioural patterns.”

“In either case, intra-accumbens infusions of SCH-23390 or sulpiride enhanced the rate of the self-administration of cocaine in socially reared controls.”

“In addition, pretreatments with sulpiride significantly potentiated the effect of cocaine on extracellular dopamine concentrations.”

“The fact that the dose of sulpiride used in these studies prevented the elevation of plasma corticosterone caused by cocaine , without blocking the stereotypy caused by cocaine, indicates that this stereotypic behavior does not require drug-induced elevation in circulating levels of corticosterone.”

“In the presence of either 1 microM cocaine or 1 microM nomifensine, sulpiride further potentiated DA overflow in the NAc but not in the aCPu.”

“Comparison with the effect of procaine on striatal ACh release suggested that the inhibition of ACh release in the presence of sulpiride was due to the local anesthetic properties of cocaine.”

“In the nucleus accumbens cocaine was about 5-fold … inhibiting ACh release than in the striatum and sulpiride was much less effective … the inhibitory effect of cocaine , suggesting that the local anesthetic effects of cocaine play a greater … regulating ACh release in this area relative to dopamine uptake blockade.”

“In the …, cocaine dose-dependently inhibited ACh release, with an IC50 of 2.… microM. At 10 microM cocaine, D2 receptor blockade by sulpiride resulted in only about a 45% reversal of the inhibition of ACh release, whereas inhibition due to either nomifensine or quinpirole was reversed by about 80%.”

“In some cells, a phaclofen‐resistant component remained that was increased by cocaine and blocked by sulpiride (1 microM).”

“Pretreatment with the D1 antagonist SCH23390, the D2 antagonist sulpiride , the D1/D2 antagonist fluphenazine, or the 5-HT2 antagonist ketanserin significantly decreased the ACTH elevations after cocaine.”

“In the rat tail artery, blockade of norepinephrine uptake by cocaine and deoxycorticosterone in the presence of sulpiride revealed two additional actions of (+)-3PPP.”

“In addition, sulpiride (1.0 micrograms in 0.5 microliter) blocked the circling behavior induced by cocaine (50 micrograms in 0.5 microliter) when administered into the medial prefrontal cortex 15 min prior to the cocaine injection.”