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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Cocaine
drug:
Substance P
Research Papers that Mention the Interaction
“Exposure of embryos to 1.5μM cocaine altered the SP mRNA expression at 24 (increasing) and 48hpf (decreasing).”
Substance P mRNA expression during zebrafish development: influence of mu opioid receptor and cocaine“This suggests that SP may act like cocaine in its absence, and may be an endogenous trigger for the reward and behaviors associated with cocaine.”
“To address the question of whether SP serves as an endogenous mediator producing cocaine‐like effects that are known to be D1‐receptor‐mediated, we tested the hypothesis that the effects of SP and cocaine on excitatory postsynaptic currents (EPSCs) in the NAc occlude one another.”
“We report here that SP and SP5–11 actions occlude the effect of cocaine and vice versa.”
Substance P and cocaine employ convergent mechanisms to depress excitatory synaptic transmission in the rat nucleus accumbens in vitro“NK1 antagonists alone did not have any rewarding or aversive effect in the CPP suggesting that substance P opposes some of the unpleasant effects of morphine and cocaine.”
“Taken together, these results suggest a direct role for substance P in the modulation of some of the actions of cocaine in the striatum of the rat brain.”
“Ibogaine and cocaine treatments altered substance P systems by increasing striatal and nigral substance P-like immunoreactivity concentration 12 h after the last drug treatment.”
“These data suggest that substance P systems may contribute to the effects of ibogaine and cocaine treatment.”
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