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Discover Supplement-Drug Interactions

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Last Updated: 7 months ago

Possible Interaction: Cocaine and Spiradoline



Research Papers that Mention the Interaction

Pretreatment with the kappa agonists enadoline (0.01 mg/kg) and spiradoline (0.3 mg/kg) or the 5-HT transport inhibitors fluoxetine (5.6 mg/kg) and citalopram (10.0 mg/kg) attenuated the priming effects of cocaine , shifting the cocaine dose–response function rightward and downward.
Psychopharmacology  •  2009  |  View Paper
Results showed that (1) intrastriatal infusion of the D1 dopamine receptor antagonist SCH‐23390 (2.5–250 pmol) resulted in a dose‐dependent …) decreased cocaine‐induced expression of c‐fos and zif 268 mRNAs in striatum in a dose‐dependent manner; (3) intrastriatal infusion of spiradoline (… cocaine , demonstrating … cortex.
The Journal of comparative neurology  •  1995  |  View Paper
Two kappa agonists, U50,488 and spiradoline , produced dose-related acute decreases in both morphine and cocaine self-administration in rats; higher doses of both agents were required to decrease rates of bar-pressing for water.
Brain Research  •  1995  |  View Paper