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Last Updated: 5 years ago

Possible Interaction: Cocaine and Somatostatin

supplement:

Cocaine

drug:

Somatostatin

Research Papers that Mention the Interaction

“Repeated cocaine also induces transcriptome-wide changes in gene expression within NAc somatostatin interneurons.”
Transcriptional and physiological adaptations in nucleus accumbens somatostatin interneurons that regulate behavioral responses to cocaine
Nature Communications  •  2018  |  View Paper
“A 5-day exposure to cocaine did not affect basal or stimulated (BDNF or PMA) production of NPY but it markedly suppressed BDNF- or PMA-stimulated production of SRIF.”
“ SRIF neurons were more susceptible than NPY neurons to the effects of cocaine.”
Differential potencies of cocaine and its metabolites, cocaethylene and benzoylecgonine, in suppressing the functional expression of somatostatin and neuropeptide Y producing neurons in cultures of fetal cortical cells.
Biochemical pharmacology  •  1997  |  View Paper
“In newborn and 15-day-old animals the exposure to cocaine produced an increase in SS concentration in the frontoparietal cortex and a decrease of this parameter in the hippocampus.”
Effect of prenatal and postnatal cocaine exposure on somatostatin content and binding in frontoparietal cortex and hippocampus of developing rat pups
Peptides  •  1991  |  View Paper