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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Cocaine
supplement:
Sodium Bicarbonate
Research Papers that Mention the Interaction
“ Cocaine produces dose-dependent slowing of cardiac conduction that is effectively reversed by sodium bicarbonate.”
“The lack of efficacy of sodium chloride suggests that the increase in arterial pH associated with sodium bicarbonate is responsible for reversal of the effects of cocaine on the ECG.”
Comparative effects of sodium bicarbonate and sodium chloride on reversing cocaine-induced changes in the electrocardiogram.“Pretreatment with NaHCO3 causes a decrease of total radioactivity ( cocaine + metabolites) in the plasma and in the liver, as well as a decrease of the levels of cocaine + norcocaine in the liver, as well as an increase of the rate of polar metabolites that are excreted in the urine.”
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