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Try: Ginkgo, Methotrexate, Glucosamine

Last Updated: 3 years ago

Possible Interaction: Cocaine and Sirolimus

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supplement:

Cocaine

drug:

Sirolimus

Research Papers that Mention the Interaction

“The mTOR inhibitor rapamycin has been shown to attenuate the behavioral effects of drugs of abuse, including cocaine.”

VTA mTOR Signaling Regulates Dopamine Dynamics, Cocaine-Induced Synaptic Alterations, and Reward

Neuropsychopharmacology • 2018 | View Paper

“Although recent studies have implicated mTORC1 signaling in drug-motivated behavior, the ineffectiveness of rapamycin , an mTORC1 inhibitor, in suppressing cocaine self-administration has raised questions regarding the specific role of mTORC1 in drug-related behaviors.”

mTORC1 Inhibition in the Nucleus Accumbens ‘Protects’ Against the Expression of Drug Seeking and ‘Relapse’ and Is Associated with Reductions in GluA1 AMPAR and CAMKIIα Levels

Neuropsychopharmacology • 2014 | View Paper

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