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Discover Supplement-Drug Interactions
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Last Updated: 2 years ago
supplement:
Cocaine
drug:
Serotonin Agents
Research Papers that Mention the Interaction
“BACKGROUND Multiple lines of evidence suggest both dopaminergic and serotonergic involvement in the reinforcing effects of cocaine.”
A pilot trial of olanzapine for the treatment of cocaine dependence.“ Serotonergic (5‐HT) mechanisms appear to mediate central effects of cocaine.”
“RationaleConsiderable evidence indicates that serotonergic (5-HT) mechanisms may mediate central effects of cocaine , and disinhibition and aggression.”
“The findings indicate that serotonergic mechanisms may be involved in cocaine dependence and may influence treatment-outcome among cocaine patients.”
“Considerable evidence indicates that serotonergic mechanisms, particularly the serotonin transporter (5HTT), may mediate central effects of cocaine and may also be involved in impulsive and aggressive behavior.”
“Overall, the present results suggest that enduring deficits occur in presynaptic serotonin neurochemistry and serotonergic adaptive mechanisms are exquisitely sensitive to chronic administration of low- and high-doses of cocaine.”
Prolonged deficits in presynaptic serotonin function following withdrawal from chronic cocaine exposure as revealed by 5-HTP-induced head-twitch response in mice“These findings strongly implicate 5-HT2C receptors in the serotonergic suppression of DA-mediated behavioral responses to cocaine and as a potential therapeutic target for cocaine abuse.”
“The present results confirm that serotonergic drugs can decrease cocaine , or cocaine/heroin, self-administration in rats, and that phentermine adds to the effect.”
“ Cocaine induced increases in serotonergic (5-HT) activity also appears to be involved in these effects.”
“These findings demonstrate that exposure to cocaine in utero can influence adrenergic, serotonergic , and dopaminergic receptors in the embryonic cerebral wall, which may lead to alteration in corticogenesis.”
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