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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Cocaine
Research Papers that Mention the Interaction
“Although few drugs with selectivity for 5-HT2 receptors have been studied systematically, a 5-HT2 agonist and several antagonists show some efficacy in enhancing and reducing, respectively, the reinforcing effects of cocaine in non-humans.”
Serotonergic mechanisms involved in the discriminative stimulus, reinforcing and subjective effects of cocaine“This effectiveness of 5-HT2C agonists to attenuate cocaine-induced enhancement of NAc DA signaling suggested that lorcaserin or other 5-HT2C agonists might also be useful to block abuse-related behavioral effects of cocaine and be useful for treating CUD [3, 5].”
“In subjects trained to lever-press according to a 300-s fixed-interval schedule of stimulus termination, pretreatment with either 5-HT2CR agonist dose-dependently and insurmountably attenuated the behavioral stimulant effects of cocaine.”
Effects of Serotonin 2C Receptor Agonists on the Behavioral and Neurochemical Effects of Cocaine in Squirrel Monkeys
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