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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Cocaine
drug:
Selegiline
Research Papers that Mention the Interaction
“ Selegiline may reduce physiological and subjective effects of cocaine.”
“Selegiline, a selective monoamine oxidase B inhibitor, indirectly modulates dopamine levels, and research suggests selegiline may modify subjective effects of cocaine.”
Transdermal selegiline and intravenous cocaine: safety and interactions“ Selegiline is an irreversible selective inhibitor of monoamine oxidase type B (MAO-B) which may affect cocaine addiction through several potential mechanisms.”
“A different effect was observed in the hippocampus, where selegiline treatment decreased metabolic activity irrespective of whether cocaine was given (main effect F = 7.70, df = 1,20, p = .012).”
“Following 7 days of selegiline treatment, the magnitude of the subjective euphoria (“high”) produced by cocaine infusion was reduced by 40% (cocaine by selegiline interaction F = 7.15, df = 1,21, p = .014).”
“Eight subjects completed a protocol that involved repeated administrations of cocaine before and after treatment with selegiline , given in extended release form, 10 mg per day.”
Effects of selegiline pretreatment on response to experimental cocaine administration
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