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Last Updated: 2 years ago

Possible Interaction: Cocaine and Selegiline



Research Papers that Mention the Interaction

Selegiline may reduce physiological and subjective effects of cocaine.
Selegiline, a selective monoamine oxidase B inhibitor, indirectly modulates dopamine levels, and research suggests selegiline may modify subjective effects of cocaine.
Psychopharmacology  •  2004  |  View Paper
Selegiline is an irreversible selective inhibitor of monoamine oxidase type B (MAO-B) which may affect cocaine addiction through several potential mechanisms.
Drug and alcohol dependence  •  2006  |  View Paper
A different effect was observed in the hippocampus, where selegiline treatment decreased metabolic activity irrespective of whether cocaine was given (main effect F = 7.70, df = 1,20, p = .012).
Following 7 days of selegiline treatment, the magnitude of the subjective euphoria (“high”) produced by cocaine infusion was reduced by 40% (cocaine by selegiline interaction F = 7.15, df = 1,21, p = .014).
Neuropsychopharmacology  •  1999  |  View Paper
Eight subjects completed a protocol that involved repeated administrations of cocaine before and after treatment with selegiline , given in extended release form, 10 mg per day.
Psychiatry Research  •  1999  |  View Paper