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Discover Supplement-Drug Interactions
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Last Updated: 4 years ago
supplement:
Cocaine
Research Papers that Mention the Interaction
“ Acute SSRI (selective serotonin reuptake inhibitor) treatment has been shown to attenuate the abuse-related effects of cocaine ; however, SSRIs have had limited success in clinical trials for cocaine abuse, possibly due to neurobiological changes that occur during chronic administration.”
Neurobiological Changes Mediating the Effects of Chronic Fluoxetine on Cocaine Use“ Serotonin-selective reuptake inhibitors (SSRIs) have been shown to enhance the locomotor stimulatory, discriminative-stimulus, and convulsive effects of cocaine in rodents.”
“Intra‐NAc administration of 0.05 μg fluoxetine resulted in a potentiation of cocaine‐induced behaviours, while the higher dose of the SSRI (5 μg) attenuated the stimulant effect of cocaine on behaviours.”
“ Cocaine and the SSRI (S)-citalopram block neurotransmitter reuptake competitively, but while cocaine is a non-selective reuptake inhibitor, (S)-citalopram is a selective SERT inhibitor.”
A short update on the structure of drug binding sites on neurotransmitter transporters
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