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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Cocaine
drug:
Scopolamine
Research Papers that Mention the Interaction
“Five cases of acute poisoning by scopolamine bought as cocaine , are reported.”
Acute scopolamine poisoning after sniffing adulterated cocaine.“Additionally, intra-VTA injection of scopolamine or mecamylamine before cocaine conditioning also attenuated cocaine CPP, demonstrating the contribution of cholinergic transmission via muscarinic and nicotinic acetylcholine receptors in CPP acquisition.”
Critical role of cholinergic transmission from the laterodorsal tegmental nucleus to the ventral tegmental area in cocaine-induced place preference“Preinfusion of scopolamine into the VTA diminished the facilitatory actions of cocaine on LDT stimulation‐evoked NAc dopamine efflux, and when infused at the peak effect of cocaine attenuated LDT‐evoked dopamine efflux to below predrug baseline levels.”
“A scopolamine dose that itself facilitated SS responding enhanced the effect of cocaine on this behavior, thus suggesting an additional involvement of cholinergic mechanism in cocaine effect.”
“An exception to this was the results derived from the third assessment indicating that animals previously treated with 20 mg/kg cocaine were impaired when challenged with scopolamine.”
“On the contrary, both THP and SCP enhanced the locomotor‐stimulant action of MAP and cocaine.”
“Administration of the cholinergic antagonist scopolamine before morphine, heroin and cocaine inhibited the expression of place preference.”
“In the majority of cases, combinations of cocaine and scopolamine maintained less self-administration than cocaine alone.”
“Drug interaction studies showed that the antimuscarinics, atropine and scopolamine , potentiated rather than attenuated the locomotor stimulant and cocaine-like discriminative-stimulus effects of cocaine , indicating that the antimuscarinic effects of the 3alpha-diphenylmethoxytropane analogs did not contribute to their diminished cocaine-like activity.”
“In contrast, when scopolamine was given in combination with cocaine for 5 days, sensitization to the locomotor‐activating effects of cocaine was prevented.”
“When scopolamine was administered 15 min prior to an acute injection of cocaine , a significant increase in the behavioral response to cocaine was seen.”
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