Possible Interaction: Cocaine and Salvinorin A

“Using … cocaine … salvA , but attenuated when administered 24 h after salvA. Quantitative real-time PCR was used to show that KOR and prodynorphin mRNA levels were … findings raise the possibility that KOR activation—as occurs upon withdrawal from chronic cocaine—modulates vulnerability to cocaine in a time-dependent manner.”

“ConclusionThe present findings demonstrate that the kappa agonist, salvinorin A , can punish self-administration of a psychotimulant, cocaine , and a mu opioid, remifentanil.”

“CONCLUSIONS Repeated sa vA mi ght trigger opponent processes such that "withdrawal" from the dysphoric effects of KOR activation is rewarding and decreases the net rewarding valence of coc aine. ”

“Repeated salvA produced a net decrease in the reward-potentiating effects of cocaine.”

“Acute administration of SalvA blocked the locomotor-stimulant effects of cocaine , whereas repeated SalvA together with concomitant exposure to activity testing chambers potentiated the locomotor response to a cocaine challenge.”

“These findings suggest that SalvA regulates the stimulant effects of cocaine through interactions with D1 receptor-mediated signaling in the dorsal striatum.”

“Differences in the interaction of salvinorin and synthetic KOPr agonists with cocaine suggest that the pharmacology of these agents may differ.”