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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Cocaine
drug:
Risperidone
Research Papers that Mention the Interaction
“A patient taking oral risperidone while using cocaine and alcohol presented with priapism shortly after long-acting, injectable risperidone was prescribed.”
Priapism and Risperidone“Nine non-treatment seeking hospitalized cocaine-dependent volunteers received 40 mg cocaine IV before and following 5 days of treatment with risperidone , 2 mg per day.”
“ Risperidone pre-treatment reduced the self-rated 'high' produced by cocaine.”
“The degree of D2 receptor blockade produced by risperidone appears to be greater than the reduction in euphoric effects produced by cocaine , suggesting that mechanisms other than those involving D2 receptors may be important in drug-induced euphoria.”
“Similar decreases in cocaine self-administration rates were obtained with the dopamine receptor antagonists olanzapine, clozapine, risperidone , fluphenazine and haloperidol.”
Muscarinic receptor agonists decrease cocaine self-administration rates in drug-naive mice.“The D2/5-HT2A antagonists MDL 28,133A and risperidone attenuated the effects of cocaine and amphetamine, but only at antagonist doses that elevated baseline self-stimulation thresholds.”
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