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Last Updated: 2 years ago

Possible Interaction: Cocaine and Risperidone

supplement:

Cocaine

Research Papers that Mention the Interaction

A patient taking oral risperidone while using cocaine and alcohol presented with priapism shortly after long-acting, injectable risperidone was prescribed.
Southern medical journal  •  2009  |  View Paper
Nine non-treatment seeking hospitalized cocaine-dependent volunteers received 40 mg cocaine IV before and following 5 days of treatment with risperidone , 2 mg per day.
Risperidone pre-treatment reduced the self-rated 'high' produced by cocaine.
The degree of D2 receptor blockade produced by risperidone appears to be greater than the reduction in euphoric effects produced by cocaine , suggesting that mechanisms other than those involving D2 receptors may be important in drug-induced euphoria.
Psychiatry Research  •  2001  |  View Paper
Similar decreases in cocaine self-administration rates were obtained with the dopamine receptor antagonists olanzapine, clozapine, risperidone , fluphenazine and haloperidol.
European journal of pharmacology  •  2000  |  View Paper
The D2/5-HT2A antagonists MDL 28,133A and risperidone attenuated the effects of cocaine and amphetamine, but only at antagonist doses that elevated baseline self-stimulation thresholds.
Pharmacology Biochemistry and Behavior  •  1995  |  View Paper