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Last Updated: 4 years ago

Possible Interaction: Cocaine and Rimonabant

supplement:

Cocaine

Research Papers that Mention the Interaction

The cannabinoid CB(1) antagonist/inverse agonist rimonabant has been shown to reduce the behavioral effects of stimuli associated with drugs of abuse, including nicotine, alcohol, cocaine , and marijuana.
Current topics in behavioral neurosciences  •  2009  |  View Paper
The present paper synthetically reviews the multiple experimental lines of evidence indicating the ability of the prototypic cannabinoid CB(1) receptor antagonist, rimonabant (also known as SR 141716), to suppress the reinforcing/rewarding properties of different drugs of abuse, including cocaine , heroin, nicotine and alcohol, in laboratory rodents.
Life sciences  •  2005  |  View Paper
Acute treatment with CP 55,940 decreased cocaine choice, whereas THC and rimonabant enhanced the reinforcing effects of cocaine.
The Journal of Pharmacology and Experimental Therapeutics  •  2020  |  View Paper
Rimonabant decreased ambulatory and vertical activity induced by cocaine.
The international journal of neuropsychopharmacology  •  2017  |  View Paper
HIGHLIGHTSExpression of conditioned locomotion to cocaine was blocked by rimonabant treatment.
Previous treatment with 10 mg/kg rimonabant blocked the expression of conditioned hyperlocomotion and behavioral sensitization to cocaine , but not acute cocaine‐induced hyperlocomotion.
Rimonabant treatment blocked the expression of behavioral sensitization to cocaine.
Treatment with 10 mg/kg rimonabant also attenuated the significant increase in c‐Fos expression in the CPu, mPFC and BLA induced by previous chronic sensitization with cocaine.
Pharmacology Biochemistry and Behavior  •  2017  |  View Paper
Moreover, systemic or intra-mPFC administration of rimonabant enhanced extinction of CPP memory induced by a high-dose (20 mg/kg) cocaine.
ResultsSystemic or intra-mPFC administration of rimonabant impaired consolidation of CPP induced by a high dose (20 or 40 mg/kg) of cocaine but facilitated that induced by a low dose (2.5, 5, or 10 mg/kg).
Psychopharmacology  •  2014  |  View Paper
In mice self-administering cocaine, rimonabant attenuated cue-induced reinstatement of cocaine self-administration, the initial burst of responding during cocaine extinction and responding during spontaneous recovery.
Drug and alcohol dependence  •  2009  |  View Paper
On the other hand, withdrawal from repeated access or exposure to cocaine and then a reinstatement of cocaine-seeking behavior or a sensitized locomotor response to a single cocaine challenge, respectively, was potently reduced by pretreatment with rimonabant.
Pharmacological reports : PR  •  2006  |  View Paper