Possible Interaction: Cocaine and Reserpine

“Depletion of the tissue stores of catecholamine with reserpineor blockade of neuronal uptake by cocaine reduced the inhibitory effect of ephe-drine and tyramine, while sensitized the action of noradrenaline.”

“There was a marked accumulation of radioactivity in the heart and spleen in control preparations as well as after cocaine and after pretreatment with reserpine.”

“Bretylium and cocaine possess the property of reducing the depletion of noradrenaline in rat hearts and spleens produced either by guanethidine or by reserpine.”

“Combining these behavioral findings with … that a higher dose of reserpine was required … response to cocaine in HR than in LR (Verheij et al., 2008), suggests that HR are more sensitive to the … than LR because cocaine can release more monoamines from storage vesicles in HR than in LR.”

“The excitatory effects of cocaine (10 mg/kg) were markedly attenuated by pretreatment with reserpine (5 mg/kg 24 and 18 h earlier) but not by α-methyl-p-tyrosine (100 mg/kg 1 h earlier).”

“ Cocaine only inhibited glutamate-induced excitation in animals pre-treated with reserpine (5 mg/kg, i.p.).”

“As anticipated, the NE responses to both AMPH (0.5, 1.25, and 5.0 mg/kg) and COC (20 mg/kg) were prevented by RES pretreatment (2.5 mg/kg, 24h).”

“Furthermore, although the DA response to COC was significantly decreased by RES , it was not completely prevented.”

“The inhibitory capacity of cocaine was further attenuated when mice were reserpinized twice prior to determination of its effects on the DOI-induced behavior.”

“Neuronal DA uptake inhibitors, nomifensine, mazindol, GBR-12909 and cocaine , all increased the rate of low Cl(-)-induced DA efflux in the reserpinized preparation.”

“The mydriatic effects of cocaine were attenuated by yohimbine and reserpine pretreatments.”