Possible Interaction: Cocaine and Raclopride

“We found that the ability of cocaine to inhibit DA uptake was increased by raclopride and that this effect was consistent across sexes.”

“Consistent with previous work, co-administration of cocaine and raclopride led to the generation of dopamine transients in NAc shell.”

“In food-restricted rats, raclopride and the D2 receptor-selective antagonist L-741,626 attenuated the effects of cocaine.”

“The locomotor hyperactivation induced by acute cocaine (10 mg/kg) was enhanced by MSX-3 (5-25 ….4 mg/kg), while CGS 21680 (0.2 mg/kg), SCH 23390 (0.25 mg/kg), raclopride (0.2-0.8 mg/kg) or ….1 mg/kg) decreased this effect of cocaine.”

“ResultsUsing the same challenge dose of cocaine in both repeated treatment conditions (i.e. 20 mg/kg), the D2 class antagonists eticlopride and raclopride were less potent in attenuating the locomotor effects of cocaine in sensitized than those in non-sensitized animals.”

“Conversely, the effects of cocaine and amphetamine on PVT Fos expression were blocked by pretreatment with the dopamine D2/3 antagonist raclopride.”

“Both SCH23390, a D-1 receptor antagonist, and raclopride , a D-2 antagonist, inhibited all behaviors induced by cocaine , suggesting that the behavioral actions of cocaine may involve the activation of D-1 and D-2 receptors.”

“Both SCH 23390 and raclopride attenuated the effects of at least one dose of cocaine.”

“The concomitant administration of both D1R and D2R antagonists, SCH 23390 (D1R selective) and raclopride (D2R selective), blocked cocaine induced-behavioral sensitization, CART over-expression, and cyclic adenosine 5'-monophosphate (cAMP)/protein kinase A (PKA)/phospho-cAMP response element-binding protein (pCREB) signal pathways.”