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Last Updated: 2 months ago

Possible Interaction: Cocaine and Raclopride

supplement:

Cocaine

Research Papers that Mention the Interaction

The concomitant administration of both D1R and D2R antagonists, SCH 23390 (D1R selective) and raclopride (D2R selective), blocked cocaine induced-behavioral sensitization, CART over-expression, and cyclic adenosine 5'-monophosphate (cAMP)/protein kinase A (PKA)/phospho-cAMP response element-binding protein (pCREB) signal pathways.
The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology  •  2015  |  View Paper
We found that the ability of cocaine to inhibit DA uptake was increased by raclopride and that this effect was consistent across sexes.
Journal of neurochemistry  •  2016  |  View Paper
Consistent with previous work, co-administration of cocaine and raclopride led to the generation of dopamine transients in NAc shell.
Front. Neural Circuits  •  2014  |  View Paper
In food-restricted rats, raclopride and the D2 receptor-selective antagonist L-741,626 attenuated the effects of cocaine.
Psychopharmacology  •  2013  |  View Paper
The locomotor hyperactivation induced by acute cocaine (10 mg/kg) was enhanced by MSX-3 (5-25 ….4 mg/kg), while CGS 21680 (0.2 mg/kg), SCH 23390 (0.25 mg/kg), raclopride (0.2-0.8 mg/kg) or ….1 mg/kg) decreased this effect of cocaine.
Brain Research  •  2006  |  View Paper
ResultsUsing the same challenge dose of cocaine in both repeated treatment conditions (i.e. 20 mg/kg), the D2 class antagonists eticlopride and raclopride were less potent in attenuating the locomotor effects of cocaine in sensitized than those in non-sensitized animals.
Psychopharmacology  •  2003  |  View Paper
Conversely, the effects of cocaine and amphetamine on PVT Fos expression were blocked by pretreatment with the dopamine D2/3 antagonist raclopride.
The Journal of Neuroscience  •  1998  |  View Paper
Both SCH23390, a D-1 receptor antagonist, and raclopride , a D-2 antagonist, inhibited all behaviors induced by cocaine , suggesting that the behavioral actions of cocaine may involve the activation of D-1 and D-2 receptors.
Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology  •  1994  |  View Paper
Both SCH 23390 and raclopride attenuated the effects of at least one dose of cocaine.
Pharmacology Biochemistry and Behavior  •  1991  |  View Paper