Possible Interaction: Cocaine and Rabbit Allergenic Extract

“ Cocaine induced activation of genes in the rabbit heart and H9C2 cells including angiotensinogen, ADRB1, and c-reactive protein (CRP).”

“ Prenatal cocaine exposure in a rabbit intravenous model has revealed selective disruption of brain development and pharmacological responsiveness.”

“Moreover, in … and rabbit heart perfused … presence of cocaine , inhibition of extraneuronal uptake markedly affected the formation of NMN.7.A linear relationship was found for all metabolites between … rate of efflux and the tissue content (both parameters being determined during steady state), indicating first-order kinetics of efflux.”

“The resultant attenuated D1 dopamine receptor-mediated signaling may ultimately underlie both long-lasting behavioral dysfunction and morphologic changes which are associated with prenatal cocaine exposure in the rabbit.”

“Preincubation of rabbit platelet-rich plasma with cocaine hydrochloride , at low and high concentrations, increased the platelet responsiveness to arachidonic acid, in terms of the aggregating response and the thromboxane production.”

“ Cocaine only potentiated the NE responses of the veins and decreased the sensitivity of rabbit and guinea pig veins to K+.”

“It is proposed that cocaine causes labilization of calcium loosely bound in the membrane in rabbit uterine segments and that this leads to contracture.”

“The resultant attenuated D1 dopamine receptor‐mediated signaling may ultimately underlie both long‐lasting behavioral dysfunction and morphologic changes which are associated with prenatal cocaine exposure in the rabbit.”