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Discover Supplement-Drug Interactions
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Last Updated: 5 years ago
supplement:
Cocaine
drug:
Quetiapine
Research Papers that Mention the Interaction
“Moreover, in some cases quetiapine is combined with other substances, such as cocaine or marijuana, to increase sedation.”
[Quetiapine in substance use disorders, abuse and dependence possibility: a review].“The addition of quetiapine to cocaine resulted in increases in low-dose cocaine choice and number of cocaine injections in four monkeys, while not affecting high-dose cocaine preference.”
“Thus, although quetiapine alone does not have abuse potential, there was evidence of enhancement of the reinforcing potency of cocaine.”
Evaluation of the Reinforcing Effect of Quetiapine, Alone and in Combination with Cocaine, in Rhesus Monkeys“ Cocaine enhanced reward by 20% and the combination of cocaine with the high dose of quetiapine lead to cancellation of each drug effect.”
“In a second study, we tested the effectiveness of a low and high dose of quetiapine (5 and 20 mg/kg) at blocking the reward enhancing effect of cocaine (4 mg/kg) in different groups of animals.”
“The low dose of quetiapine did not alter baseline reward but completely blocked the effect of cocaine.”
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