supp.ai
Discover Supplement-Drug Interactions
Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 3 years ago
supplement:
Cocaine
drug:
Psychotropic Drugs
Research Papers that Mention the Interaction
“Increasing evidence suggests that psychoactive cannabinoid use in adolescence enhances the behavioral effects of cocaine.”
Cannabinoid exposure in rat adolescence reprograms the initial behavioral, molecular, and epigenetic response to cocaine“Consumption of alcohol or cannabis with cocaine enhances subjective responses to cocaine, concomitant with changes in cocaine metabolism that increase blood cocaine levels, and, in the case of alcohol, produce the psychoactive metabolite cocaethylene.”
“Through palmitoylating selective AMPA receptor subunits, cocaine activity dependently regulates trafficking and subcellular localization of the receptor in NAc neurons and dynamically controls psychomotor sensitivity to the psychoactive drug in vivo.”
Reversible Palmitoylation Regulates Surface Stability of AMPA Receptors in the Nucleus Accumbens in Response to Cocaine In Vivo“Other psychoactive drugs were either ineffective (imipramine) or they showed moderate inhibitory effects (amitryptyline and cocaine).”
“The short-term … of ps chotropic substances, i n … cas e cocaine, a pparently triggers a fast modification of D1-receptor expression in terms of focal synaptic plasticity and could, hence, bring forth a … shift in the D1/D2 ratio, which eventually might lead to a fortification of limbic and drug-associated afferents.”
Stimulating the Addictive Brain
Help us improve supp.ai, we'd love to hear your feedback: Submit Feedback