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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Cocaine
drug:
Propranolol
Research Papers that Mention the Interaction
“ Propranolol may reduce symptoms of autonomic arousal associated with early cocaine abstinence and improve treatment outcome.”
Effectiveness of propranolol for cocaine dependence treatment may depend on cocaine withdrawal symptom severity.“Excerpt To the Editor:Robin and colleagues (1) showed that propranolol blunts the pulmonary edema and ascites in mice given massive doses of cocaine.”
“Recently, propranolol has been shown to benefit patients in cocaine withdrawal.”
“ Propranolol 1 mg/min intravenously may specifically antagonise the sympathomimetic effects of cocaine.”
“Because d-propranolol has been shown to block the direct effects of cocaine on the pregnant rabbit uterus, we also evaluated the ability of d-propranolol (2 x 10(-6) mol/L) to block the effect of cocaine on catecholamine uptake.”
“Moreover, the leftward shift of the noradrenaline curves promoted by uptake blockers cocaine and corticosterone) and β-adrenoceptor antagonist ( propranolol ) was reduced in the vas deferens of treated group.”
Influence of acute treatment with sibutramine on the sympathetic neurotransmission of the young rat vas deferens.“Furthermore, prazosin and propranolol administration appeared to facilitate the conditioned aversive effects of cocaine.”
“Conversely, beta-adrenergic blockade with propranolol inhibits the effects of cocaine and epinephrine on CAM expression and decreases PMN adhesion to the coronary endothelium.”
“ Cocaine also reduced contractility [dP/dt50 (−341±80 mm Hg/s)] and increased systemic vascular resistance (+2703±339 dyn·s·cm−5) in the resence of propranolol.”
“In addition, propranolol , a drug that enhances the increase in vascular resistance to cocaine , also increases toxicity to cocaine in vascular responders.”
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