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Last Updated: 2 years ago

Possible Interaction: Cocaine and Propranolol

supplement:

Cocaine

Research Papers that Mention the Interaction

Propranolol may reduce symptoms of autonomic arousal associated with early cocaine abstinence and improve treatment outcome.
Drug and alcohol dependence  •  2001  |  View Paper
Excerpt To the Editor:Robin and colleagues (1) showed that propranolol blunts the pulmonary edema and ascites in mice given massive doses of cocaine.
Annals of internal medicine  •  1989  |  View Paper
Recently, propranolol has been shown to benefit patients in cocaine withdrawal.
Cognitive and behavioral neurology : official journal of the Society for Behavioral and Cognitive Neurology  •  2005  |  View Paper
Propranolol 1 mg/min intravenously may specifically antagonise the sympathomimetic effects of cocaine.
Postgraduate medical journal  •  1998  |  View Paper
Because d-propranolol has been shown to block the direct effects of cocaine on the pregnant rabbit uterus, we also evaluated the ability of d-propranolol (2 x 10(-6) mol/L) to block the effect of cocaine on catecholamine uptake.
Obstetrics and gynecology  •  1991  |  View Paper
Moreover, the leftward shift of the noradrenaline curves promoted by uptake blockers cocaine and corticosterone) and β-adrenoceptor antagonist ( propranolol ) was reduced in the vas deferens of treated group.
European journal of pharmacology  •  2014  |  View Paper
Furthermore, prazosin and propranolol administration appeared to facilitate the conditioned aversive effects of cocaine.
Pharmacology Biochemistry and Behavior  •  2008  |  View Paper
Conversely, beta-adrenergic blockade with propranolol inhibits the effects of cocaine and epinephrine on CAM expression and decreases PMN adhesion to the coronary endothelium.
American journal of physiology. Heart and circulatory physiology  •  2005  |  View Paper
Cocaine also reduced contractility [dP/dt50 (−341±80 mm Hg/s)] and increased systemic vascular resistance (+2703±339 dyn·s·cm−5) in the resence of propranolol.
Basic Research in Cardiology  •  2004  |  View Paper
In addition, propranolol , a drug that enhances the increase in vascular resistance to cocaine , also increases toxicity to cocaine in vascular responders.
European journal of pharmacology  •  2003  |  View Paper
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