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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Cocaine
supplement:
Progestins
Research Papers that Mention the Interaction
“How progestins' effects on these processes may underlie response to drugs of abuse is considered and new findings which demonstrate interactions between progestins and cocaine are presented.”
Progestins influence motivation, reward, conditioning, stress, and/or response to drugs of abuse“ Cocaine can alter secretion of progestogens , such as progesterone (P), and its neuroactive metabolite, 5alpha-pregnan-3alpha-ol-20-one (3alpha,5alpha-THP).”
“We hypothesize that some sex/hormonal differences in initiation phase responses to cocaine may be related to formation of progestogens.”
Low doses of cocaine decrease, and high doses increase, anxiety-like behavior and brain progestogen levels among intact rats
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