Possible Interaction: Cocaine and Progesterone

“There is increasing preclinical and clinical evidence showing that the hormone progesterone attenuates the behavioral effects of cocaine , and this effect is primarily observed in females.”

“These results are in contrast with previous studies showing that progesterone attenuates the subjective response to cocaine and nicotine.”

“ Progesterone treatment also attenuated the subjective ratings of high and feel the effect of last dose in response to cocaine but did not affect cocaine self-administration behavior.”

“These results suggest that progesterone attenuates some of the physiological and subjective effects of cocaine in both male and female participants.”

“We recently reported that progesterone treatment attenuated some of the subjective effects of smoked cocaine in female cocaine users.”

“For individual items of CEQ, progesterone treatment was associated with diminished rating of "feel the effect of last dose" in response to cocaine.”

“These preliminary results suggest that acute progesterone treatment, given during the early follicular phase, may attenuate some of the subjective effects of cocaine.”

“No significant gender differences have been found in the pharmacokinetics of cocaine taken alone; yet, in women pharmacological sensitivity to the drug seems to vary in relation to menstrual cycle; moreover, progesterone attenuates subjective effects of cocaine in women.”

“In terms of potential hormonal mechanisms for these differences, the hormone progesterone attenuates the subjective response to cocaine.”

“This review paper presents a recent update on data collected in our Human Cocaine Challenge Laboratory and our Non-human Primate Laboratory, including analysis of cocaine pharmacokinetics, sex differences, the menstrual cycle, and the role of progesterone in modulating the response to cocaine.”

“Clinical studies suggest that progesterone attenuates the subjective effects of cocaine.”

“Constantly changing progesterone serum levels in female humans and rats affect the female's reinforcement responses to cocaine and may in part contribute to the known sex differences in cocaine responses.”

“In rats progesterone also reduces the reinforcement effects of cocaine attenuates acquisition, escalation, reinstatement of cocaine self-administration, and cocaine-seeking behaviors.”

“ Progesterone also counteracts the facilitatory effects of estrogen on cocaine self-administration and psychomotor activation.”

“Due to the profound effects of progesterone in the modulation of CNS plasticity, the modulation of progesterone plasma level by cocaine may have implications for reproductive processes and neuronal functions of women.”

“ Progesterone plasma levels were also increased after a single dose of cocaine (15 mg/kg).”

“OBJECTIVES Fluctuations in progesterone levels during the menstrual cycle have been shown to affect physiological and subjective effects of cocaine.”

“AIMS Exogenous progesterone has been shown to attenuate the rewarding effects of cocaine.”

“Moreover, the modulatory effects of progesterone on reducing the positive effects of cocaine may have some clinical utility in treating stimulant abusers.”