Possible Interaction: Cocaine and Prazosin

“In the presence of cocaine, prazosin exhibited higher potency against the revealed α1D-adrenoceptor mediated component (e.g. pKB 9.12).”

“In the presence of cocaine, prazosin exhibited higher potency against the α1D-adrenoceptor-mediated component. (”

“Furthermore, prazosin and propranolol administration appeared to facilitate the conditioned aversive effects of cocaine.”

“Moreover, prazosin exerted antagonism of the S(−)PRO-like effect of (±)PRO or R(+)PRO but produced only partial antagonism of the S(−)PRO-like effect of cocaine.”

“Prazosin partially attenuated the stimulus effect of cocaine (8 mg/kg) but completely blocked the cocaine-like effects of (±), S(−), and R(+)PRO.ConclusionsPRO and cocaine exhibited cross-substitution, but their stimulus effects were antagonized differentially by prazosin.”

“We now assessed whether prazosin could counter the effect of previous exposure to cocaine to enhance subsequent self-administration behavior.”

“In both regions, cocaine–prazosin treatment attenuates the effects of cocaine.”

“Blockade of α1 receptors by prazosin did not enhance cocaine's ability to inhibit firing rate and bursting, but it did enable cocaine to inhibit the SO.”

“Each dose of prazosin produced a significant attenuation of the locomotor effects of a limited range of cocaine doses (i.e. 10 and/or 20 mg/kg cocaine, but not 40 mg/kg cocaine).”

“The impact of prazosin on cocaine-induced hypophagia paralleled that noted for locomotion in that administration of prazosin significantly attenuated the hypophagic action of 20 mg/kg cocaine , but not that of 40 mg/kg cocaine.”

“Co‐administration of equimolar doses (250 pmoles) of prazosin , naftopidil, yohimbine or rauwolscine significantly reversed those effects elicited by cocaine on cEEG, hEEG and ICP.”

“ Prazosin significantly attenuated the cardiac output but not the coronary vascular responses to cocaine.”