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Discover Supplement-Drug Interactions

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Last Updated: 2 years ago

Possible Interaction: Cocaine and Pramipexole

supplement:

Cocaine

Research Papers that Mention the Interaction

An 8-week in vivo exposure to pramipexole (0.7 mg free base , 3 times a day) or ropinirole (12 mg, once daily), but not levodopa/carbidopa (100/25 mg, 3 times a day), significantly reduced the mean fluorescence intensity of the dopamine transporter in peripheral blood lymphocytes.
Pharmacological reports : PR  •  2011  |  View Paper
Caution should be used when prescribing pramipexole to patients that may also use cocaine.
Pramipexole produced upwards of two-fold increases in positive subjective effects ratings following cocaine.
Psychiatry Research  •  2015  |  View Paper
The three dopamine agonists with highest reported D3 receptor selectivity in vitro, pramipexole , quinelorane and PD128,907, decreased self-administration of a high dose of cocaine in rats as a result of a leftward shift in the cocaine dose-effect function.
Neuroreport  •  1997  |  View Paper
Pramipexole , a D3-preferring agonist, in a dose of 0.5 mg/kg induced over 80% substitution for cocaine , and a weaker one (ca.
Polish journal of pharmacology  •  1997  |  View Paper