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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Cocaine
drug:
Pramipexole
Research Papers that Mention the Interaction
“An 8-week in vivo exposure to pramipexole (0.7 mg free base , 3 times a day) or ropinirole (12 mg, once daily), but not levodopa/carbidopa (100/25 mg, 3 times a day), significantly reduced the mean fluorescence intensity of the dopamine transporter in peripheral blood lymphocytes.”
Dopaminergic drug-induced modulation of the expression of the dopamine transporter in peripheral blood lymphocytes in Parkinson's disease.“Caution should be used when prescribing pramipexole to patients that may also use cocaine.”
“ Pramipexole produced upwards of two-fold increases in positive subjective effects ratings following cocaine.”
“The three dopamine agonists with highest reported D3 receptor selectivity in vitro, pramipexole , quinelorane and PD128,907, decreased self-administration of a high dose of cocaine in rats as a result of a leftward shift in the cocaine dose-effect function.”
D3 receptor test in vitro predicts decreased cocaine self‐administration in rats“ Pramipexole , a D3-preferring agonist, in a dose of 0.5 mg/kg induced over 80% substitution for cocaine , and a weaker one (ca.”
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