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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Cocaine
drug:
Physostigmine
Research Papers that Mention the Interaction
“This effect of cocaine was inhibited by pretreatment with α-methyl-p-tyrosine, haloperidol, and physostigmine , but not with FLA-63, phenoxybenzamine and tetrabenazine.”
Possible role of dopamine in central effects of cocaine as measured by apomorphine gnawing test in mice“Pretreatment with cocaine at ineffective doses as well as at an effective one potentiated the effects of an ineffective as well as of an effective dose of physostigmine in C57 mice, while it antagonized the effects of the inhibitor of cholinesterase enzymes on memory consolidation in DBA mice.”
Strain-dependent effects of cocaine on memory storage improvement induced by post-training physostigmine“In 4 of 11 cats, the physostigmine pretreatment produced a significant decrease in mean arterial blood pressure followed by lethal cardiorespiratory arrest when cocaine was administered.”
“ Physostigmine pretreatment significantly altered the lethality of cocaine , increasing the LD 50 from 82.5 mg/kg to 96.9 mg/kg in male F344 rats.”
“ Physostigmine produced dose-related decreases in the self-administration of both cocaine and procaine.”
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