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Discover Supplement-Drug Interactions
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Last Updated: 2 years ago
supplement:
Cocaine
drug:
Phenylpropanolamine
Research Papers that Mention the Interaction
“As observed previously for juvenile PPA treatment, adolescent PPA administration blunted the dopamine and norepinephrine response to acute cocaine , prevented the development of catecholamine sensitization but did not influence cocaine‐induced elevations in serotonin.”
PRECLINICAL STUDY: Protracted ‘anti‐addictive’ effects of adolescent phenylpropanolamine exposure in C57BL/6J mice“Pre-adolescent PPA exposure completely prevented the capacity of cocaine to elevate extracellular levels of catecholamines in the nucleus accumbens, but facilitated the development of cocaine-induced glutamate sensitization.”
“To examine the possibility that pre-adolescent PPA exposure may induce neuroadaptations that influence behavioral and neurochemical responding to cocaine , C57BL/6J mice were pretreated with PPA (0–40 mg/kg) during postnatal days 21–31.”
“Previously, we reported that juvenile PPA exposure alters the developmental trajectory of catecholamine and amino acid neurotransmitter systems in the nucleus accumbens (NAC), impacting the motivational valence of cocaine in later life.”
Enduring dysregulation of nucleus accumbens catecholamine and glutamate transmission by developmental exposure to phenylpropanolamine
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