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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Cocaine
drug:
Phenylephrine
Research Papers that Mention the Interaction
“Cardiac complication from use of cocaine and phenylephrine in nasal septoplasty.”
Enoxaparin-Induced Massive Abdominal Wall Hematoma Presenting in Hypovolemic Shock.“This letter is in response to a case reported in theArchivesby Ashchi et al 1 titled, "Cardiac Complication From Use of Cocaine and Phenylephrine in Nasal Septoplasty."”
“ Cocaine and guanethidine enhanced the motor response to adrenaline, noradrenaline and phenylephrine while the action of dopamine was blocked by these two drugs.”
“Intra-mPFC injection of phenylephrine , an α1 adrenoceptor agonist, before the posttest session without stress exposure significantly enhanced cocaine CPP.”
Acute restraint stress augments the rewarding memory of cocaine through activation of α1 adrenoceptors in the medial prefrontal cortex of mice“Repeated administration of cocaine affected baroreflex activity and impaired vascular responsiveness to both sodium nitroprusside and phenylephrine.”
“ Cocaine HCl, 2 x 10(-3) M, was found to inhibit contractions by phenylephrine ; EC50s were increased (P<0.01) and Emax's were decreased (51.3+/-16.4% vs. 89.8+/-10.6%, P<0.01).”
“An inhibition of neuronal uptake with cocaine caused a small but significant increase in the potency of (−)-phenylephrine.”
“Reboxetine (10-7 M) and cocaine (10-5-2 × 10-4 M) enhanced the contractions evoked by phenylephrine and norepinephrine.”
“In the rat epididymal vas deferens the potency of noradrenaline and phenylephrine was increased in the presence of neuronal and extra-neuronal uptake blockers, cocaine and beta-oestradiol, but these did not alter that of methoxamine.”
“ Cocaine potentiated the initial fast but not the secondary slow responses to phenylephrine suggesting that neuronal uptake limits the initial fast but not the secondary slow response to phenylephrine.”
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