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Discover Supplement-Drug Interactions
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Last Updated: 5 years ago
supplement:
Cocaine
drug:
Phentolamine
Research Papers that Mention the Interaction
“Pretreatment of hearts with 10−5 M, but not with 10−6 M, phentolamine prevented the increase of transmitter overflow by cocaine.”
Effect of phentolamine on noradrenaline uptake and release“ Cocaine induced rhythmic contractions of the vas deferens, which were prevented by phentolamine.”
“ Phentolamine attenuated the blood pressure decrease following cocaine and propranolol attenuated the heart rate decrease following cocaine.”
“The depressant effect of cocaine (2 mg/kg) on postganglionic cardiac SNA was attenuated after treatment with phentolamine (5 mg/kg i.v.).”
“Significant EPI release by cocaine would result in “epinephrine reversal” after phentolamine pretreatment.”
“ Phentolamine , prazosin and yohimbine also reduced the tachycardiac effect of cocaine , although these effects were dose-dependent only for yohimbine, which also significantly elevated baseline heart rate.”
“The non-selective alpha adrenoceptor antagonist phentolamine produced a dose-dependent antagonism of the pressor effect of cocaine , as did the alpha-1 selective antagonist prazosin.”
“The pressor response to 3 mg/kg of cocaine was antagonized by alpha adrenoceptor blockade with phentolamine , whereas the tachycardiac response to cocaine was antagonized by beta adrenoceptor blockade with propranolol.”
“In the atrial preparations the effect persisted after 24 h. The effect was prevented by pretreatment with sotalol or cocaine , but potentiated by phentolamine pretreatment.”
“The administration of a single 5-mg/kg dose of phentolamine antagonized the decrease in glutathione levels and the elevation of aminotransferase activity caused by a 60-mg/kg dose of cocaine.”
“Cocaine did reduce the afterdischarges, and this action of cocaine was partially antagonized by phentolamine and reserpine.”
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