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Discover Supplement-Drug Interactions

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Last Updated: 4 months ago

Possible Interaction: Cocaine and Phentermine



Research Papers that Mention the Interaction

cocaine produced tolerance to the stimulus … properties of methylphenidate, phenmetrazine, and phentermine , such that doses approximately two-fold higher than those used acutely were necessary to reproduce the original effect; the … cocaine stimulus was decreased greater than four-fold; and fenfluramine still failed to substitute for the cocaine stimulus.
Psychopharmacology  •  2004  |  View Paper
These results show that phentermine is effective in decreasing cocaine self-administration and suggest that it may be an effective medication for cocaine abuse.
The Journal of pharmacology and experimental therapeutics  •  1999  |  View Paper
Due to the importance of mesolimbic dopamine (DA) in mediating cocaine reinforcement, we hypothesized that phentermine might attenuate the effects of cocaine on DA transmission.
Our findings suggest that phentermine may antagonize the subjective effects of cocaine in humans via a DA mechanism.
Neuroreport  •  1996  |  View Paper
Combining topiramate and phentermine robustly decreased cocaine self-administration.
Maintenance on topiramate and phentermine alone significantly decreased cocaine self-administration although these effects were modest in magnitude.
Drug and alcohol dependence  •  2020  |  View Paper