supp.ai
Discover Supplement-Drug Interactions
Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 2 years ago
supplement:
Cocaine
drug:
Phentermine
Research Papers that Mention the Interaction
“Combining topiramate and phentermine robustly decreased cocaine self-administration.”
“Maintenance on topiramate and phentermine alone significantly decreased cocaine self-administration although these effects were modest in magnitude.”
Topiramate-phentermine combinations reduce cocaine self-administration in humans.“… cocaine produced tolerance to the stimulus … properties of methylphenidate, phenmetrazine, and phentermine , such that doses approximately two-fold higher than those used acutely were necessary to reproduce the original effect; the … cocaine stimulus was decreased greater than four-fold; and fenfluramine still failed to substitute for the cocaine stimulus.”
Substitution and cross-tolerance profiles of anorectic drugs in rats trained to detect the discriminative stimulus properties of cocaine“These results show that phentermine is effective in decreasing cocaine self-administration and suggest that it may be an effective medication for cocaine abuse.”
“Due to the importance of mesolimbic dopamine (DA) in mediating cocaine reinforcement, we hypothesized that phentermine might attenuate the effects of cocaine on DA transmission.”
“Our findings suggest that phentermine may antagonize the subjective effects of cocaine in humans via a DA mechanism.”
Help us improve supp.ai, we'd love to hear your feedback: Submit Feedback