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Last Updated: 2 years ago

Possible Interaction: Cocaine and Phenobarbital

supplement:

Cocaine

Research Papers that Mention the Interaction

Exposure to from 50 to 500 microM of either cocaine or norcocaine resulted in toxicity in hepatocytes from phenobarbital-induced rats.
Drug metabolism and disposition: the biological fate of chemicals  •  1996  |  View Paper
It is concluded that patients who have taken phenobarbital or some other potential inducers of the microsomal drug‐metabolizing enzymes may have a somewhat increased tolerance to the systemic effects of cumulative doses of licocaine.
Acta anaesthesiologica Scandinavica  •  1970  |  View Paper
The immunosuppressive activity of cocaine in female B6C3F1 mice was markedly increased when mice were pretreated with phenobarbital , a cytochrome P-450 inducer.
The Journal of pharmacology and experimental therapeutics  •  1996  |  View Paper
PB pretreatment augmented Vmax (6-fold), but not KM, of cocaine N-demethylation.
Drug metabolism and disposition: the biological fate of chemicals  •  1992  |  View Paper
Diazepam and phenobarbital protected against convulsions induced by 60 mg/kg cocaine (90% convulsions alone).
Life sciences  •  1991  |  View Paper
Phenobarbital induction greatly increased … potency of cocaine in vitro, with nearly complete loss of cell viability at cocaine concentrations in culture as low as 0.01 mM. The … 10 microM SK&F-525-A to the cultures blocked cocaine cytotoxicity in cells from both naive and phenobarbital-induced rats.
Toxicology letters  •  1990  |  View Paper
Phenobarbital pretreatment of females of the four inbred strains resulted in enhancement of the hepatotoxic response to cocaine in the C3H, DBA, and Balb mice.
Journal of biochemical toxicology  •  1988  |  View Paper
Cocaine was N-dealkylated by hepatic microsomes, and PB pretreatment enhanced hepatic N-dealkylation of cocaine.
PB plus cocaine treatment produced a dose-related increase in serum glutamic-pyruvic transaminase activity and periportal necrosis.
PB plus cocaine treatment reduced hepatic glutathione concentrations by 40%.
PB pretreatment increased by 85% the cocaine covalently bound to hepatic protein.
Toxicology and applied pharmacology  •  1978  |  View Paper